BDBM50192689 CHEMBL3934636

SMILES CC(C)(C)NC(=O)CN1CCC(CC1)CNC(=O)c2cc(cc(c2)Cl)F

InChI Key InChIKey=JOCLITFYIMJMNK-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50192689   

TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192689(CHEMBL3934636)
Affinity DataIC50: 37nMAssay Description:Inhibition of human T-type calcium channel Cav3.1 expressed in CHO cells assessed as inhibition of calcium tail current at -90 mV holding potential m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192689(CHEMBL3934636)
Affinity DataIC50: 37nMAssay Description:Inhibition of human CaV 3.1 by manual patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192689(CHEMBL3934636)
Affinity DataIC50: 86nMAssay Description:Inhibition of human CaV 3.3 by manual patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192689(CHEMBL3934636)
Affinity DataIC50: 73nMAssay Description:Inhibition of human CaV 3.2 by manual patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192689(CHEMBL3934636)
Affinity DataIC50: 86nMAssay Description:Inhibition of T-type calcium channel Cav3.3 (unknown origin) expressed in HEK293 cells assessed as calcium influx by Fluo-4-AM dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192689(CHEMBL3934636)
Affinity DataIC50: 73nMAssay Description:Inhibition of recombinant T-type calcium channel Cav3.2 (unknown origin) expressed in HEK293 cells assessed as inhibition of CaCl2-induced calcium in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192689(CHEMBL3934636)
Affinity DataIC50: 37nMAssay Description:Inhibition of Cav3.1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192689(CHEMBL3934636)
Affinity DataIC50: 73nMAssay Description:Inhibition of Cav3.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192689(CHEMBL3934636)
Affinity DataIC50: 86nMAssay Description:Inhibition of Cav3.3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed