BDBM50189617 (3R)-1'-(9-anthrylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine::(3R)-1'-(anthracen-9-ylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine::CHEMBL208943::US20240398737, Compound CP 640186::{(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin]-3-yl}(morpholin-4-yl)methanone

SMILES O=C([C@@H]1CCCN(C1)C1CCN(CC1)C(=O)c1c2ccccc2cc2ccccc12)N1CCOCC1

InChI Key InChIKey=LDQKDRLEMKIYMC-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50189617   

TargetAcetyl-CoA carboxylase 2(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 70nMAssay Description:Inhibition of N-terminal His-tagged human recombinant ACC2 expressed in high five insect cells by ATP consumption assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 2(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 78.1nMAssay Description:Table 3: Human ACC1 (Cat #50202 Lot #120830) and ACC2 (Cat #50201 Lot #160217) were obtained from BPS Biosciences, San Diego, CA 92121. Human ACC1 ha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

TargetAcetyl-CoA carboxylase 1(Human)
Espervita Therapeutics

US Patent
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 2.14E+3nMAssay Description:Table 3: Human ACC1 (Cat #50202 Lot #120830) and ACC2 (Cat #50201 Lot #160217) were obtained from BPS Biosciences, San Diego, CA 92121. Human ACC1 ha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

TargetAcetyl-CoA carboxylase 2(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 61nMAssay Description:Inhibitory activity against rat ACC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 53nMAssay Description:Inhibitory activity against rat ACC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 2(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant ACC2 expressed in baculovirus/sf9 systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Human)
Espervita Therapeutics

US Patent
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant ACC1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 2(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human ACC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Human)
Espervita Therapeutics

US Patent
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 550nMAssay Description:Inhibition of human ACC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 230nMAssay Description:Inhibition of obese Zucker rat ACC1 assessed as reduction in hepatic malonyl-coA level preincubated for 15 mins measured after 1.5 hrs using Malachit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase(Rat)
Astrazeneca Research and Development

Curated by ChEMBL
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 170nMAssay Description:Inhibition of ACC2 in obese Zucker rat assessed as reduction in hepatic malonyl-coA level preincubated for 15 mins measured after 1.5 hrs using Malac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 2(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant ACC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Human)
Espervita Therapeutics

US Patent
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 910nMAssay Description:Inhibition of N-terminal His-tagged human recombinant ACC1 expressed in high five insect cells by ATP consumption assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 590nMAssay Description:Inhibition of N-terminal His-tagged rat recombinant ACC1 expressed in high five insect cells by ATP consumption assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 92nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Human)
Espervita Therapeutics

US Patent
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 456nMAssay Description:Inhibition of human recombinant ACC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase(Rat)
Astrazeneca Research and Development

Curated by ChEMBL
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 61nMAssay Description:Inhibition of rat ACC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 53nMAssay Description:Inhibition of rat ACC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 2(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 194nMAssay Description:Inhibition of human recombinant ACC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase(Rat)
Astrazeneca Research and Development

Curated by ChEMBL
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 55nMAssay Description:Inhibition of rat acetyl-CoA carboxylase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 55nMAssay Description:Inhibition of rat acetyl-CoA carboxylase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Human)
Espervita Therapeutics

US Patent
LigandPNGBDBM50189617({(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin...)
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant ACC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed