BDBM50187132 3,5-Dimethoxy-4-hydroxybenzoic acid::4-hydroxy-3,5-dimethoxybenzoic acid::CHEMBL1414::Syringic acid

SMILES COc1cc(cc(c1O)OC)C(=O)O

InChI Key InChIKey=JMSVCTWVEWCHDZ-UHFFFAOYSA-N

Data  14 KI  4 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50187132   

TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research Ahmedabad

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetAlpha-(1,3)-fucosyltransferase 7(Human)
Schering-Plough Research Institute

LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataIC50: 2.00E+5nMpH: 7.3 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2012
Entry Details Article
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research Ahmedabad

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Kinki University

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate preincubated for 10 mins followed by enzyme addition measured after 20 mins by microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataKi:  3.19E+3nMAssay Description:Inhibition of human CA2 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataKi:  4.15E+3nMAssay Description:Inhibition of human CA1 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataKi:  6.34E+3nMAssay Description:Inhibition of human CA5A by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 6(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataKi:  7.55E+3nMAssay Description:Inhibition of human CA6 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 7(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataKi:  7.81E+3nMAssay Description:Inhibition of human CA7 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataKi:  8.20E+3nMAssay Description:Inhibition of human CA9 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 3(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataKi:  8.58E+3nMAssay Description:Inhibition of human CA3 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataKi:  9.01E+3nMAssay Description:Inhibition of human CA12 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 14(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataKi:  9.14E+3nMAssay Description:Inhibition of human CA14 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataKi:  1.06E+4nMAssay Description:Inhibition of human CA4 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 13(Mouse)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of mouse CA13 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 5B, mitochondrial(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataKi:  3.54E+4nMAssay Description:Inhibition of human CA5B by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataKi:  9.19E+5nM ΔG°:  -4.14kcal/molepH: 7.4 T: 2°CAssay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion using s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataKi:  6.95E+5nM ΔG°:  -4.31kcal/molepH: 7.4 T: 2°CAssay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion using s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2011
Entry Details Article
PubMed