BDBM50184869 1-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-3-(2-phenylacetyl)thiourea::CHEMBL205372::N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(2-phenylacetyl)thiourea

SMILES COc1cc2c(ccnc2cc1OC)Oc3ccc(cc3)NC(=S)NC(=O)Cc4ccccc4

InChI Key InChIKey=BRXZUOJFGVQTAB-UHFFFAOYSA-N

Data  1 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50184869   

TargetMast/stem cell growth factor receptor Kit(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184869(N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(2-...)
Affinity DataIC50: 202nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184869(N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(2-...)
Affinity DataIC50: 28nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50184869(N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(2-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50184869(N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(2-...)
Affinity DataKi:  2nMAssay Description:Inhibition of human activated c-Met by PK/LDH coupled kinetic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)