BDBM50181392 (R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-1-benzylpyrrolidine-2-carboxamide::1-benzyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperidine]-1-yl]propyl-D-prolineamide::CHEMBL201945

SMILES c1ccc(cc1)CN2CCC[C@@H]2C(=O)NCCCN3CCC4(CC3)c5ccccc5CO4

InChI Key InChIKey=MAKMQGKJURAJEN-UHFFFAOYSA-N

Data  1 KI  5 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50181392   

TargetDelta-type opioid receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181392(1-benzyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181392(1-benzyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperid...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181392(1-benzyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperid...)
Affinity DataIC50: 0.150nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTP-gamma-S binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181392(1-benzyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperid...)
Affinity DataIC50: 2.50E+3nMAssay Description:Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181392(1-benzyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperid...)
Affinity DataIC50: 6.70E+3nMAssay Description:Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181392(1-benzyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperid...)
Affinity DataIC50: 0.270nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181392(1-benzyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperid...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]N/OFQ from human recombinant NOP receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)