BDBM50181148 1-(3,4-dichlorophenyl)-3-(N-hydroxyacetamido)propylphosphonic acid::CHEMBL204107

SMILES CC(=O)N(CC[C@H](c1ccc(c(c1)Cl)Cl)P(=O)(O)O)O

InChI Key InChIKey=ABGCTQYLJZGMBM-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50181148   

Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50181148(1-(3,4-dichlorophenyl)-3-(N-hydroxyacetamido)propy...)
Affinity DataKd:  360nMAssay Description:Binding affinity to Mycobacterium tuberculosis DXR assessed as dissociation constant by spectrofluorimetric analysis in presence of NADPH and MnCl2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Escherichia coli (strain K12))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50181148(1-(3,4-dichlorophenyl)-3-(N-hydroxyacetamido)propy...)
Affinity DataIC50: 119nMAssay Description:Inhibition of recombinant Escherichia coli DXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50181148(1-(3,4-dichlorophenyl)-3-(N-hydroxyacetamido)propy...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant DXR expressed in Escherichia coli BL21 (DE3) using DXP as substrate and MgCl2 as cofactor preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)