BDBM50180054 CHEMBL199824::[O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione

SMILES COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1

InChI Key InChIKey=GKTQBPYMIGXPKG-UHFFFAOYSA-N

Data  42 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 44 hits for monomerid = 50180054   

Target5-hydroxytryptamine receptor 1A(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataEC50:  0.0100nMAssay Description:Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataEC50:  0.0500nMAssay Description:Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  8.5nMAssay Description:Binding affinity to dopamine D4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  9.10nMAssay Description:Binding affinity to human 5HT7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  22nMAssay Description:Binding affinity to dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  24nMAssay Description:Binding affinity to adrenergic alpha-2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  32nMAssay Description:Binding affinity to adrenergic alpha-1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  42nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  61nMAssay Description:Binding affinity to adrenergic beta-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  63nMAssay Description:Binding affinity to dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  100nMAssay Description:Binding affinity to human 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  120nMAssay Description:Binding affinity to human 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  150nMAssay Description:Binding affinity to histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  229nMAssay Description:Binding affinity to human 5HT5A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  302nMAssay Description:Binding affinity to histamine H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  316nMAssay Description:Binding affinity to adrenergic alpha-2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  407nMAssay Description:Binding affinity to DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  476nMAssay Description:Binding affinity to adrenergic beta-1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  480nMAssay Description:Binding affinity to sigma1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  1.01E+3nMAssay Description:Binding affinity to adrenergic alpha-2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  6.14E+3nMAssay Description:Binding affinity to SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  6.98E+3nMAssay Description:Binding affinity to NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi:  7.40E+3nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to CB1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adenosine A2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to Delta opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to muscarinic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to dopamine D5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic beta-3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVasopressin V1a/V1b receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to vasopressin 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to vasopressin 2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adenosine A4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to MDR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChromaffin granule amine transporter(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to VMAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adenosine A3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to CB2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTumor necrosis factor receptor superfamily member 16(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to neurotrophin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to VMAT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50180054([O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed