BDBM50179207 3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine::CHEMBL120077::JNJ-10198409

SMILES COc1cc2Cc3c(Nc4cccc(F)c4)[nH]nc3-c2cc1OC

InChI Key InChIKey=ZDNURMVOKAERHZ-UHFFFAOYSA-N

Data  34 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50179207   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 185nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 4.58E+4nMAssay Description:Inhibitory activity against bFGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 378nMAssay Description:Inhibitory activity against FYNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 45nMAssay Description:Inhibitory activity against PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 5.67E+4nMAssay Description:Inhibitory activity against CDK7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 45nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 22nMAssay Description:Inhibition of cAblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 100nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 378nMAssay Description:Inhibition of FynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Cdk2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Cdk4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 4.58E+4nMAssay Description:Inhibition of bFGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human EGFR at 10000 nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Cdk7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibitory activity against GSK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against PKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCasein kinase I isoform alpha/delta/epsilon/gamma-1/gamma-2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibitory activity against Casein Kinase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 4.20nMAssay Description:Inhibitory activity against PDGFRbeta kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibitory activity against VEGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 3nMAssay Description:Antiproliferative activity against PDGF-BB stimulated HCASMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Cdk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 185nMAssay Description:Inhibitory activity against c-SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(JNJ-10198409 | 3-fluoro-N-(6,7-dimethoxy-2,4-dihyd...)
Affinity DataIC50: 22nMAssay Description:Inhibitory activity against c-ABLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed