BDBM50166066 CHEMBL362991::H-Tyr-Pro-Phe-Pro-NH2::MORPHICEPTIN::Tyr-Pro-Phe-Pro-NH2::[D-Pro4]morphiceptin

SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(N)=O

InChI Key InChIKey=LSQXZIUREIDSHZ-UHFFFAOYSA-N

Data  9 KI  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50166066   

TargetDelta-type opioid receptor(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50166066(CHEMBL362991 | Tyr-Pro-Phe-Pro-NH2 | [D-Pro4]morph...)
Affinity DataIC50: 3.69E+3nMAssay Description:In vitro inhibitory activity against delta opioid receptor using mouse vas deferens (MVD) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of California

Curated by ChEMBL
LigandPNGBDBM50166066(CHEMBL362991 | Tyr-Pro-Phe-Pro-NH2 | [D-Pro4]morph...)
Affinity DataIC50: 552nMAssay Description:In vitro inhibitory activity against mu opioid receptor using guinea pig ileum (GPI) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM50166066(CHEMBL362991 | Tyr-Pro-Phe-Pro-NH2 | [D-Pro4]morph...)
Affinity DataEC50:  741nMAssay Description:Agonist activity at human recombinant MOR expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM50166066(CHEMBL362991 | Tyr-Pro-Phe-Pro-NH2 | [D-Pro4]morph...)
Affinity DataIC50: 56.6nMAssay Description:Displacement of [3H]DAMGO from Wistar rat mu opioid receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM50166066(CHEMBL362991 | Tyr-Pro-Phe-Pro-NH2 | [D-Pro4]morph...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H][Ile5,6]deltorphin 2 from delta opioid receptor in Wistar rat brain membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM50166066(CHEMBL362991 | Tyr-Pro-Phe-Pro-NH2 | [D-Pro4]morph...)
Affinity DataIC50: 320nMAssay Description:Inhibitory activity against non-selective opiate receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM50166066(CHEMBL362991 | Tyr-Pro-Phe-Pro-NH2 | [D-Pro4]morph...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]DAMGO from MOR in Wistar rat brain homogenate by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM50166066(CHEMBL362991 | Tyr-Pro-Phe-Pro-NH2 | [D-Pro4]morph...)
Affinity DataKi:  80nMAssay Description:Inhibition of DAMGO (Tyr-[D-Ala]-Gly-[NMe-Phe]-Gly-ol) binding to rat brain mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM50166066(CHEMBL362991 | Tyr-Pro-Phe-Pro-NH2 | [D-Pro4]morph...)
Affinity DataKi:  135nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Wistar rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM50166066(CHEMBL362991 | Tyr-Pro-Phe-Pro-NH2 | [D-Pro4]morph...)
Affinity DataKi:  135nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membrane after 3 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetNeuropeptides B/W receptor type 1(Human)
Addiction Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50166066(CHEMBL362991 | Tyr-Pro-Phe-Pro-NH2 | [D-Pro4]morph...)
Affinity DataKi:  145nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2011
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM50166066(CHEMBL362991 | Tyr-Pro-Phe-Pro-NH2 | [D-Pro4]morph...)
Affinity DataKi:  150nMAssay Description:Binding affinity towards non-selective opiate receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM50166066(CHEMBL362991 | Tyr-Pro-Phe-Pro-NH2 | [D-Pro4]morph...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H][Ile5,6]deltorphin-2 from DOR in Wistar rat brain homogenate by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2017
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM50166066(CHEMBL362991 | Tyr-Pro-Phe-Pro-NH2 | [D-Pro4]morph...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]nor-BNI from KOR in Dunkin Hartley guinea pig brain homogenate by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2017
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Medical University of Lodz

Curated by ChEMBL
LigandPNGBDBM50166066(CHEMBL362991 | Tyr-Pro-Phe-Pro-NH2 | [D-Pro4]morph...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in Wistar rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed