BDBM50164400 CHEMBL3799694

SMILES CCNC(=O)C1=C(SC2=NC(=CC(=O)N12)Cn3c(cc(n3)C(F)(F)F)Cl)C

InChI Key InChIKey=MQDBLHZAPZLITE-UHFFFAOYSA-N

Data  6 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50164400   

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50164400(CHEMBL3799694)
Affinity DataEC50:  436nMAssay Description:Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 2(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50164400(CHEMBL3799694)
Affinity DataEC50:  7.32E+4nMAssay Description:Positive allosteric modulation of human GluA2 AMPAR flop isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50164400(CHEMBL3799694)
Affinity DataEC50:  3.70E+4nMAssay Description:Positive allosteric modulation of human GluA2 AMPAR flip isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50164400(CHEMBL3799694)
Affinity DataEC50:  440nMAssay Description:Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 2(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50164400(CHEMBL3799694)
Affinity DataEC50:  7.30E+4nMAssay Description:Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50164400(CHEMBL3799694)
Affinity DataEC50:  3.70E+4nMAssay Description:Positive allosteric modulation of human GluA2 receptor flip isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed