BDBM50164398 CHEMBL3799213

SMILES c1c(nn(c1Cl)CC2=CC(=O)N3C(=C(SC3=N2)C(F)(F)F)[C@@H]4C[C@H]4C#N)C(F)(F)F

InChI Key InChIKey=FTIBNGABJNFFAI-UHFFFAOYSA-N

Data  5 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50164398   

TargetGlutamate receptor 2(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50164398(CHEMBL3799213)
Affinity DataEC50:  9.10E+3nMAssay Description:Positive allosteric modulation of human GluA2 AMPAR flip isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2C(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50164398(CHEMBL3799213)
Affinity DataEC50:  7.40E+3nMAssay Description:Positive allosteric modulation of GluN1/GluN2C NMDAR (unknown origin) expressed in Dox-inducible cells by BD calcium indicator dye based-fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50164398(CHEMBL3799213)
Affinity DataEC50:  21nMAssay Description:Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 2(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50164398(CHEMBL3799213)
Affinity DataEC50:  5.50E+3nMAssay Description:Positive allosteric modulation of human GluA2 AMPAR flop isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50164398(CHEMBL3799213)
Affinity DataEC50:  6.20E+3nMAssay Description:Positive allosteric modulation of GluN1/GluN2D NMDAR (unknown origin) expressed in Dox-inducible cells by BD calcium indicator dye based-fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)