BDBM50157881 CHEMBL3787614
SMILES Nc1ncnc2n(cc(-c3cccc(OC[C@@H]4CCCO4)c3)c12)[C@@H]1C[C@H](CN2CCC2)C1
InChI Key InChIKey=UYHKCQAFCWYUAF-UHFFFAOYSA-N
Data 50 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 50 hits for monomerid = 50157881
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 84nMAssay Description:Inhibition of IGF-1 receptor (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFRalpha (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Her1 (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of PI3K-beta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of PI3K-alpha (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of IGF-1 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 930nMAssay Description:Inhibition of Ins receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of EphB4 receptor (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of Ret (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Jak1 (unknown origin)More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPKAPK2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of PI4Kbeta (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of KDR (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AURKA (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of EphA4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of VPS34 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPK1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cMET (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of full length IGF-1 receptor (unknown origin) transfected in Ba/F3 cells assessed as cell proliferationMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK4D1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Antagonist activity at human GST-tagged IGF-1R (950 to 133 residues) expressed in baculovirus after 5 mins in presence of [gamma33P]-ATP by top count...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 5(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPKAPK5 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of PDK1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BTK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of RET (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of EphB4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAP3K8 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPK14 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 930nMAssay Description:Inhibition of insulin receptor (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRKACA (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TYK2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2A (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of full length insulin receptor (unknown origin) transfected in Ba/F3 cells assessed as cell proliferationMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ALK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SYK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cKIT (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of LCK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of PI3Kdelta (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair