BDBM50157879 CHEMBL1614712

SMILES [H][C@]1(CN2CCC2)C[C@]([H])(C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12

InChI Key InChIKey=AECDBHGVIIRMOI-UHFFFAOYSA-N

Data  70 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 70 hits for monomerid = 50157879   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of PI3K-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 61nMAssay Description:Inhibition of IGF-1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Jak1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of Ret (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphB4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Ins receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 130nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of PI3K-beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Her1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of RET (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRKACA (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ZAP70 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 86nMAssay Description:Inhibition of human recombinant IGF-1R N-terminal His-tagged (950 to 1337 residues) expressed in baculovirus infected Sf21 measured after 20 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInsulin receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of GST-tagged recombinant human IR ( 919 to 1343 residues) autophosphorylation expressed in mouse NIH-3T3-A14 cells preincubated for 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 86nMAssay Description:Inhibition of GST-tagged recombinant human IGF1R ( 950 to 1337 residues) autophosphorylation expressed in mouse NWT-21 cells preincubated for 20 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 60nMAssay Description:Antagonist activity at human GST-tagged IGF-1R (950 to 133 residues) expressed in baculovirus after 5 mins in presence of [gamma33P]-ATP by top count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of BTK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of cKIT (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAP3K8 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of ALK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of FGFR2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of SRC (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ABL1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPKAPK2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 244nMAssay Description:Inhibition of full length insulin receptor (unknown origin) transfected in Ba/F3 cells assessed as cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetEphrin type-A receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphA4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPK1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2A (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 65nMAssay Description:Inhibition of full length IGF-1 receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of KDR (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of LYN (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR3 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3B (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 20nMAssay Description:Inhibition of full length IGF-1 receptor (unknown origin) transfected in Ba/F3 cells assessed as cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ACVR1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPKAPK5 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphB4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 61nMAssay Description:Inhibition of IGF-1 receptor (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 130nMAssay Description:Displacement of [3H]-dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AXL (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
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