BDBM50154375 Adenosine receptor agonist, 16::Ribavirin::Tribavirin::cid_37542::med.21724, Compound 180

SMILES c1nc(nn1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N

InChI Key InChIKey=IWUCXVSUMQZMFG-UHFFFAOYSA-N

Data  3 KI  5 IC50  1 Kd  6 EC50

PDB links: 5 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50154375   

TargetGlycogen synthase kinase-3 beta(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataEC50: >3.00E+5nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetGenome polyprotein(EV71)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of Enterovirus 71 Shenzhen/120F1/09 capsid infected in human RD cells assessed as reduction in virus-induced cell death after 72 hrs by CC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataIC50: 6.23E+5nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Bonn

LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataEC50:  1.10E+5nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetGenome polyprotein(ZIKV)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataEC50:  2.08E+4nMAssay Description:Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity after 72 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase catalytic subunit(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataEC50:  2.40E+4nMAssay Description:Inhibition of RdRP activity in Influenza A virus A/PR/8/34 (H1N1) infected in HEK293T cells co-transfected with NP/PA/PB1/PB2/pPolI-Flu-ffLuc/pRL-SV4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase catalytic subunit(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of RdRP activity in Influenza A virus A/PR/8/34(H1N1) infected in HEK293T cells incubated for 24 hrs by minireplicon based dual luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataKd:  8.40E+3nMAssay Description:Binding affinity to eIF4E (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetAdenosine receptor A1(Mouse)
Medical College of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataKi:  4.43E+3nMAssay Description:Displacement of [3H]N6-R-phenylisopropyladenosine from mouse A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Uppsala University

LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataKi:  7.41E+3nMAssay Description:Radioligand binding assays were performed using membranes prepared from CHO (hA1AR or hA3AR) or HEK293 (hA2AAR) cells stably expressing a single hAR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Uppsala University

LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataKi:  7.41E+3nMAssay Description:Displacement of [3H]N6-R-phenylisopropyladenosine from human A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed