BDBM50151245 CHEMBL1229516

SMILES CNC(=O)[C@@H](NC(=O)[C@H](CCCc1ccccc1)[C@H](C)N(O)C=O)C(C)(C)C

InChI Key InChIKey=GHVMTHKJUAOZJP-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50151245   

TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human ADAM-10 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 1 hr by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of ADAM-10 in human L540 cells assessed as reduction in pervanadate-induced TNFalpha shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of ADAM-10 in human L540 cells assessed as reduction in pervanadate-induced soluble MICB shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ADAM-10 in human L540 cells assessed as reduction in pervanadate-induced soluble ULBP3 shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ADAM-17 in human L428 cells assessed as reduction in pervanadate-induced soluble ALCAM shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of ADAM-10 in human L428 cells assessed as reduction in pervanadate-induced TNFalpha shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of ADAM-10 in human L428 cells assessed as reduction in pervanadate-induced soluble MICB shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of ADAM-10 in human L428 cells assessed as reduction in pervanadate-induced soluble ULBP3 shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ADAM-17 in human KM-H2 cells assessed as reduction in pervanadate-induced soluble ALCAM shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ADAM-10 in human KM-H2 cells assessed as reduction in pervanadate-induced TNFalpha shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 860nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 88nMAssay Description:Inhibition of recombinant human MMP-14 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 3 hrs by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of recombinant human MMP-9 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 3 hrs by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant human MMP-2 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 3 hrs by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 125nMAssay Description:Inhibition of human MMP-1 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 3 hrs by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ADAM-10 in human KM-H2 cells assessed as reduction in pervanadate-induced soluble ULBP3 shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50151245(CHEMBL1229516)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of ADAM-10 in human KM-H2 cells assessed as reduction in pervanadate-induced soluble MICB shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2017
Entry Details Article
PubMed