BDBM50150484 (Z)-9-octadecenoic acid::(Z)-Octadec-9-enoic acid::CHEMBL8659::OLEATE::Octadec-9-enoic acid::oleaic acid::oleicacid

SMILES CCCCCCCC\C=C/CCCCCCCC(=O)O

InChI Key InChIKey=ZQPPMHVWECSIRJ-UHFFFAOYSA-N

Data  7 KI  17 IC50  3 Kd  4 EC50

PDB links: 346 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50150484   

TargetTrypsin(Pig)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of pig pancreatic trypsin after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataEC50:  9.00E+4nMAssay Description:Activation of recombinant His-tagged SIRT6 (unknown origin) deacetylase activity expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataEC50:  8.90E+4nMAssay Description:Activation of human SIRT6 deacetylase activity expressed in Escherichia coli BL21(DE3) expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataEC50:  3.60E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells by luciferase/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor subfamily 4 group A member 2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataKd:  5.00E+4nMAssay Description:Binding affinity towards Nurr1 ligand binding domain (unknown origin) measured by tryptophan fluorescence spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrate incubated for 30 mins by photometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 600nMAssay Description:Inhibition of PPAR-alpha (unknown origin) by SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PDB3D3D Structure (crystal)
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 4.10E+3nMAssay Description:Displacement of [3H]BRL49653 from Homo sapiens (human) PPARgamma receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PDB3D3D Structure (crystal)
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 5.30E+3nMAssay Description:Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 600nMAssay Description:Displacement of [3H]GW2331 from Homo sapiens (human) PPARalpha receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily V member 2(Rat)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 2(Rat)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataKd:  900nMAssay Description:Binding affinity to L-FABP low binding affinity site by titration calorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFatty acid-binding protein, liver(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataKd:  200nMAssay Description:Binding affinity to L-FABP high binding affinity site by titration calorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Rat)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against rat liver microsomal Acyl coenzyme A:cholesterol acyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Human)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against human Acyl coenzyme A:cholesterol acyltransferase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Human)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against human Acyl coenzyme A:cholesterol acyltransferase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBcl-2-like protein 11(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataEC50: >3.50E+5nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2011
Entry Details
PCBioAssay
TargetTissue factor(Human)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of amidolytic activity of human tissue factor/human factor 7aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, adipocyte(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 2.61E+4nMAssay Description:Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP4 expressed in Escherichia coli BL21 (DE3) cells after 3 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Sheep)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of sheep COX2-mediated prostaglandin biosynthesis using [1-14C]arachidonic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Bovine)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of bovine COX1-mediated prostaglandin biosynthesis using [1-14C]arachidonic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
University of Puerto Rico

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of DNA topoisomerase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAromatase(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataIC50: 3.27E+4nMAssay Description:Inhibition of aromatase in human placental microsomes by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataKi:  180nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFatty acid-binding protein, adipocyte(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataKi:  185nMAssay Description:Displacement of 1,8-ANS from aFABP by fluorescence based-assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFatty acid-binding protein 5(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataKi:  248nMAssay Description:Displacement of 1,8-ANS from eFABP by fluorescence based-assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFatty acid-binding protein, adipocyte(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of 1,8-ANS from His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFatty acid-binding protein, liver(Rat)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataKi:  2.90E+3nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFatty-acid amide hydrolase 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of FAAHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetSeed linoleate 13S-lipoxygenase-1(Soybean)
University of California

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataKi:  2.20E+4nMAssay Description:Binding affinity to soybean LO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed