BDBM50150025 CHEMBL3770256

SMILES c1cncc2c1C(=O)NC=N2

InChI Key InChIKey=QMOPAFMMLWUTKI-UHFFFAOYSA-N

Data  7 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50150025   

TargetLysine-specific demethylase 4C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50150025(CHEMBL3770256)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of N-terminal his-tagged human KDM4C expressed in Escherichia coli BL21(DE3) using trimethylated peptide substrate by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50150025(CHEMBL3770256)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal his-tagged full-length human KDM4C transfected in U2OS cells assessed as inhibition of H3K9Me3 demethylation for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4B(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50150025(CHEMBL3770256)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged KDM4B (1 to 500 residues) expressed in baculovirus infected sf9 cells using biotin-H3K9me3 as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 3A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50150025(CHEMBL3770256)
Affinity DataIC50: 2.62E+4nMAssay Description:Inhibition of KDM3A (unknown origin) using biotin-H3K9me2 (1 to 21 residues) as substrate preincubated for 15 mins followed by substrate addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 5B(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50150025(CHEMBL3770256)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50150025(CHEMBL3770256)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5C(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50150025(CHEMBL3770256)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details Article
PubMed