BDBM50148552 CHEMBL3770150

SMILES CCOc1ccc(cc1NC(=O)c2cccc(c2)C(=O)O)C(=O)C

InChI Key InChIKey=GFOBMGVVDGTGAJ-UHFFFAOYSA-N

Data  1 IC50  7 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50148552   

TargetCREB-binding protein(Human)
University of Z£Rich

Curated by ChEMBL
LigandPNGBDBM50148552(CHEMBL3770150)
Affinity DataKd:  670nMAssay Description:Competitive binding affinity to human His-tagged CREBBP expressed in T7 phage-infected Escherichia coli BL21(DE3) cells incubated for 1 hr by bromosc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
University of Z£Rich

Curated by ChEMBL
LigandPNGBDBM50148552(CHEMBL3770150)
Affinity DataKd: >5.00E+4nMAssay Description:Competitive binding affinity to human BRD4 bromodomain 1 expressed in T7 phage-infected Escherichia coli BL21(DE3) cells incubated for 1 hr by bromos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Z£Rich

Curated by ChEMBL
LigandPNGBDBM50148552(CHEMBL3770150)
Affinity DataKd: >5.00E+4nMAssay Description:Competitive binding affinity to human BRD4 bromodomain 2 expressed in T7 phage-infected Escherichia coli BL21(DE3) cells incubated for 1 hr by bromos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Z£Rich

Curated by ChEMBL
LigandPNGBDBM50148552(CHEMBL3770150)
Affinity DataKd: >5.00E+4nMAssay Description:Competitive binding affinity to human BRD2 bromodomain 1 expressed in T7 phage-infected Escherichia coli BL21(DE3) cells incubated for 1 hr by bromos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Z£Rich

Curated by ChEMBL
LigandPNGBDBM50148552(CHEMBL3770150)
Affinity DataKd: >5.00E+4nMAssay Description:Competitive binding affinity to human BRD2 bromodomain 2 expressed in T7 phage-infected Escherichia coli BL21(DE3) cells incubated for 1 hr by bromos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Z£Rich

Curated by ChEMBL
LigandPNGBDBM50148552(CHEMBL3770150)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to human His-tagged CREBBP expressed in Escherichia coli BL21(DE3) cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
University of Z£Rich

Curated by ChEMBL
LigandPNGBDBM50148552(CHEMBL3770150)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of human recombinant GST-tagged CREBBP using non acetylated ligand 1 as substrate incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
University of Z£Rich

Curated by ChEMBL
LigandPNGBDBM50148552(CHEMBL3770150)
Affinity DataKd:  770nMAssay Description:Competitive binding affinity to partial length human CREBBP expressed in Escherichia coli BL21 after 1 hr by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)