BDBM50138662 6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-aminomethyl-phenyl)-amide::6-[(Z)-AMINO(IMINO)METHYL]-N-[4-(AMINOMETHYL)PHENYL]-2-NAPHTHAMIDE::CHEMBL324168::N-(4-(aminomethyl)phenyl)-6-carbamimidoyl-2-naphthamide::uPa_9

SMILES [H]/N=C(/c1ccc2cc(ccc2c1)C(=O)Nc3ccc(cc3)CN)N

InChI Key InChIKey=NLBDETRVUYOIHQ-UHFFFAOYSA-N

Data  13 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50138662   

TargetProthrombin(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins by spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataKi:  40nMAssay Description:Photometric_Method1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2017
Entry Details
D3R

TargetUrokinase-type plasminogen activator(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataKi:  40nMAssay Description:Inhibition of urokinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataKi:  40nMAssay Description:Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins by spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataKi:  40nMAssay Description:Binding affinity to human urokinase-type plasminogen activator (microPa).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataKi:  40nM ΔG°:  -10.1kcal/molepH: 7.4 T: 2°CAssay Description:Abbott uPA__Urokinase Human - Ki(uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2012
Entry Details PubMed
TargetSerine protease 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataKi:  2.08E+3nMAssay Description:Binding affinity against porcine trypsin was determined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataKi:  7.17E+3nMAssay Description:Binding affinity against human plasma kallikrein.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataKi:  1.60E+4nMAssay Description:Binding affinity towards human plasmin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataKi:  5.84E+4nMAssay Description:Binding affinity towards human Tissue type plasminogen activator.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataKi:  5.84E+4nMAssay Description:Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138662(CHEMBL324168 | N-(4-(aminomethyl)phenyl)-6-carbami...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity against human alpha thrombin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed