BDBM50136758 CHEMBL3753249

SMILES Cc1ncc(o1)C(=O)Nc2ccc(c(c2)Cl)C(=O)NCC3(CCOCC3)c4ccc(cc4)OC

InChI Key InChIKey=WOVOBLGUSQNZJX-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50136758   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50136758(CHEMBL3753249)
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50136758(CHEMBL3753249)
Affinity DataIC50: 2.23E+3nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50136758(CHEMBL3753249)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50136758(CHEMBL3753249)
Affinity DataIC50: 2.24E+3nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50136758(CHEMBL3753249)
Affinity DataIC50: 690nMAssay Description:Inhibition of tankyrase in WNT3a-stimulated human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)