BDBM50135141 6-[(2,5-Dichloro-phenylamino)-methyl]-pyrido[2,3-d]pyrimidine-2,4-diamine::6-{[(2,5-dichlorophenyl)amino]methyl}pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL145979

SMILES c1cc(c(cc1Cl)NCc2cc3c(nc(nc3nc2)N)N)Cl

InChI Key InChIKey=RSPDQFOJWPXTPN-UHFFFAOYSA-N

Data  2 KI  3 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50135141   

TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50135141(6-[(2,5-Dichloro-phenylamino)-methyl]-pyrido[2,3-d...)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of dihydrofolate reductase from rat liver.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50135141(6-[(2,5-Dichloro-phenylamino)-methyl]-pyrido[2,3-d...)
Affinity DataIC50: 440nMAssay Description:Inhibition of dihydrofolate reductase from pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50135141(6-[(2,5-Dichloro-phenylamino)-methyl]-pyrido[2,3-d...)
Affinity DataIC50: 300nMAssay Description:Inhibition of dihydrofolate reductase from Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50135141(6-[(2,5-Dichloro-phenylamino)-methyl]-pyrido[2,3-d...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of recombinant Pneumocystis carinii DHFR expressed in Escherichia coli Rosetta Gami B (DE3) by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50135141(6-[(2,5-Dichloro-phenylamino)-methyl]-pyrido[2,3-d...)
Affinity DataKi:  24nMAssay Description:Inhibition of recombinant human DHFR expressed in Escherichia coli Rosetta Gami B (DE3) by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)