BDBM50134320 CHEMBL3746293

SMILES Cc1c(ccc(c1NC(=O)c2cc3ccccc3s2)F)C4=NNC(=O)C(=C4)Nc5cc6n(n5)CCN(C6)C

InChI Key InChIKey=MZSDTUIZKGUVHK-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50134320   

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50134320(CHEMBL3746293)
Affinity DataIC50: 14nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50134320(CHEMBL3746293)
Affinity DataIC50: 230nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50134320(CHEMBL3746293)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50134320(CHEMBL3746293)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MELK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50134320(CHEMBL3746293)
Affinity DataIC50: 924nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Mouse)
Genentech

Curated by ChEMBL
LigandPNGBDBM50134320(CHEMBL3746293)
Affinity DataIC50: 91nMAssay Description:Inhibition of BTK in Balb/c mouse B cells assessed as inhibition of anti-IgM-stimulated CD86 expression by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50134320(CHEMBL3746293)
Affinity DataIC50: 3nMAssay Description:Inhibition of BTK (unknown origin) by Lanthascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)