BDBM50128294 CHEMBL3629013

SMILES c1cnc(cc1C#N)Nc2cc(n(n2)C3CCCC3)C4CCN(CC4)C5COC5

InChI Key InChIKey=GMTAOJMPNXLKJI-UHFFFAOYSA-N

Data  1 KI  16 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50128294   

TargetMast/stem cell growth factor receptor Kit(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: 5.34E+5nMAssay Description:Inhibition of Kit (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: 536nMAssay Description:Inhibition of Dox inducible human DLK transfected in HEK293 cells assessed as reduction in JNK phosphorylation incubated for 5.5 hrs measured by Hoec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 8(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of JNK1 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MKK7 (unknown origin) using KFMMTPpYVVTR substrate incubated for 1 hr measured by MpTPpYV probe-based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MKK4 (unknown origin) using KFMMTPpYVVTR substrate incubated for 1 hr measured by MpTPpYV probe-based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: 1.19E+6nMAssay Description:Inhibition of TrkB (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: 4.64E+5nMAssay Description:Inhibition of TrkA (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: 1.01E+6nMAssay Description:Inhibition of Src (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of JNK2 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: 6.82E+5nMAssay Description:Inhibition of GSK3beta (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: 3.22E+5nMAssay Description:Inhibition of Flt3 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of CSF1R (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MLK3 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MLK2 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MLK1 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of JNK3 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataKi:  42nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)