BDBM50126443 CHEMBL30678::N*1*-[7-(4-Dimethylamino-phenyl)-[1,6]naphthyridin-5-yl]-propane-1,3-diamine::N1-(7-(4-(dimethylamino)phenyl)-1,6-naphthyridin-5-yl)propane-1,3-diamine

SMILES CN(C)c1ccc(cc1)c2cc3c(cccn3)c(n2)NCCCN

InChI Key InChIKey=RIWJHDIYQSQOAT-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50126443   

TargetTyrosine-protein kinase SYK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126443(N1-(7-(4-(dimethylamino)phenyl)-1,6-naphthyridin-5...)
Affinity DataIC50: 34nMAssay Description:Inhibitory activity against spleen tyrosine kinase (SYK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126443(N1-(7-(4-(dimethylamino)phenyl)-1,6-naphthyridin-5...)
Affinity DataIC50: 951nMAssay Description:Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126443(N1-(7-(4-(dimethylamino)phenyl)-1,6-naphthyridin-5...)
Affinity DataIC50: 552nMAssay Description:Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126443(N1-(7-(4-(dimethylamino)phenyl)-1,6-naphthyridin-5...)
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126443(N1-(7-(4-(dimethylamino)phenyl)-1,6-naphthyridin-5...)
Affinity DataIC50: 34nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)