BDBM50126317 1-{2-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-acetyl}-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile::CHEMBL30059

SMILES c1ccc2c(c1)cccc2C3=C(CCN(C3)C(=O)Cc4cncn4Cc5ccc(cc5)C#N)C#N

InChI Key InChIKey=KXPIURLUHSBSHE-UHFFFAOYSA-N

Data  2 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50126317   

LigandPNGBDBM50126317(1-{2-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-acetyl}...)
Affinity DataIC50: 2.20nMAssay Description:In vitro inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50126317(1-{2-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-acetyl}...)
Affinity DataIC50: 4.50E+3nMAssay Description:In vitro inhibition of geranylgeranyltransferase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50126317(1-{2-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-acetyl}...)
Affinity DataEC50:  3.90nMAssay Description:Inhibition of Ras farnesylation in Human Ha-Ras oncogene-transformed BALB/c 3T3 cells (EJ3 cells)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)