BDBM50121980 CHEMBL347537::N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmethyl)-amino]-benzamide

SMILES O=C(Nc1cccc(c1)-c1cncc2ccccc12)c1ccccc1NCc1ccncc1

InChI Key InChIKey=IGMQBINYIPIDJQ-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50121980   

TargetVascular endothelial growth factor receptor 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 9nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of Cyclin-dependent kinase 1 (CDK-1) expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of Met proto-oncogene tyrosine kinase (c-Met) expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 5.33E+3nMAssay Description:In vitro inhibition of c-Abl tyrosine kinase expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 6.80E+3nMAssay Description:In vitro inhibition of Tyrosine protein kinase receptor TIE-2 (Tek) expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of VEGFR induced autophosphorylation of human Vascular endothelial growth factor receptor 2 (VEGFR2) transfected in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 6.40E+4nMAssay Description:In vitro inhibition of Insulin-like growth factor I receptor expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 5.10E+3nMAssay Description:In vitro inhibition of Fibroblast growth factor receptor expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 130nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 1 (VEGFR-1) expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of Epidermal growth factor receptor (HER-1,ErbB) expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 52nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 3 [VEGFR-3(Flt-4)] expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of c-SRC kinase expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 99nMAssay Description:In vitro inhibition of Colony stimulating factor 1 receptor (CSF-1R) expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 357nMAssay Description:In vitro inhibition of Platelet-derived growth factor receptor beta expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 105nMAssay Description:In vitro inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed