BDBM50121720 (1-METHYL-1H-IMIDAZOL-2-YL)-(3-METHYL-4-{3-[(PYRIDIN-3-YLMETHYL)-AMINO]-PROPOXY}-BENZOFURAN-2-YL)-METHANONE::CHEMBL355497::Non peptidic, 5

SMILES Cc1c2c(cccc2OCCCNCc3cccnc3)oc1C(=O)c4nccn4C

InChI Key InChIKey=VZBQJKIOAOUYJL-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50121720   

TargetGlycylpeptide N-tetradecanoyltransferase(Yeast)
Nippon Roche Research Center

LigandPNGBDBM50121720(CHEMBL355497 | Non peptidic, 5 | (1-METHYL-1H-IMID...)
Affinity DataIC50: 1nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycylpeptide N-tetradecanoyltransferase 1(Human)
Nippon Roche Research Center

LigandPNGBDBM50121720(CHEMBL355497 | Non peptidic, 5 | (1-METHYL-1H-IMID...)
Affinity DataIC50: 69nMAssay Description:Inhibition activity against C. albicans Nmt and human Nmt as assessed by IC50 using myristoyl-CoA (0.5 uM) and peptide substrate GLTISKLFRR-NH2 (0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2011
Entry Details Article
PubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Human)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50121720(CHEMBL355497 | Non peptidic, 5 | (1-METHYL-1H-IMID...)
Affinity DataIC50: 1.30nMAssay Description:In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2018
Entry Details Article
PubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Human)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50121720(CHEMBL355497 | Non peptidic, 5 | (1-METHYL-1H-IMID...)
Affinity DataIC50: 6.90E+4nMAssay Description:In vitro inhibitory activity against human Nmt (HsNmt) using 0.5 uM peptide GNAASAR-R-NH2 and 0.5 uM myristoyl-CoAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2018
Entry Details Article
PubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Human)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50121720(CHEMBL355497 | Non peptidic, 5 | (1-METHYL-1H-IMID...)
Affinity DataIC50: 3.00E+4nMAssay Description:In vitro inhibitory activity against Aspergillus fumigatus Nmt (AfNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2018
Entry Details Article
PubMed