BDBM50118792 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID::2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid::CHEMBL139393

SMILES C1CNCc2c1c(c(s2)NC(=O)C(=O)O)C(=O)O

InChI Key InChIKey=ZIBMATWHOAGNTR-UHFFFAOYSA-N

Data  17 KI  3 IC50

PDB links: 15 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50118792   

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sejong University

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of PTP1B by pNPP hydrolase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sejong University

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of PTP1B after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sejong University

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of PTP1B after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sejong University

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi:  230nMAssay Description:Inhibition of PTP1B I219A mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sejong University

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi:  290nMAssay Description:Inhibition of PTP1B (1 to 321 residues) (unknown origin) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sejong University

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi:  290nMpH: 5.5Assay Description:Inhibitory effect against recombinant human protein-tyrosine phosphatase 1B (PTP1B), using p-nitrophenyl phosphate substrate at pH 5.5.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
University of Miami

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi:  290nMAssay Description:Inhibition of PTPN2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
University of Miami

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi:  710nMAssay Description:Inhibition of TCPTP I220A mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sejong University

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi:  4.70E+3nMAssay Description:Inhibition of human recombinant Protein-tyrosine phosphatase 1B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sejong University

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of wild type PTP1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
University of Miami

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi:  9.40E+3nMpH: 7.0Assay Description:Inhibition of T cell protein tyrosine phosphatase (TC-PTP) at pH 7.0More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
University of Miami

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of TCPTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sejong University

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi:  1.15E+4nMAssay Description:Inhibition of PTP1B after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sejong University

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi:  5.01E+4nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein phosphatase C(Human)
University of Miami

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi:  5.90E+4nMAssay Description:Inhibition of PTPRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase alpha(Human)
University of Miami

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi: >2.00E+6nMAssay Description:Inhibition of PTPRAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase epsilon(Human)
University of Miami

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi:  1.10E+6nMAssay Description:Inhibition of PTPREMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
University of Miami

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi: >2.00E+6nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
University of Miami

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi: >2.00E+6nMAssay Description:Inhibition of PTPRFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Human)
University of Miami

Curated by ChEMBL
LigandPNGBDBM50118792(2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-...)
Affinity DataKi:  5.60E+5nMAssay Description:Inhibition of PTPRBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed