BDBM50112617 CHEMBL3608786

SMILES Cc1ccc(cc1NC(=O)c2cnc3n2cccc3)CNC(=O)Nc4cccc(c4)F

InChI Key InChIKey=ZPVUIOVIUFJGHO-UHFFFAOYSA-N

Data  2 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50112617   

TargetDiscoidin domain-containing receptor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112617(CHEMBL3608786)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of DDR2 (unknown origin) after 1 hr by time resolved fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMast/stem cell growth factor receptor Kit(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112617(CHEMBL3608786)
Affinity DataIC50: 19nMAssay Description:Inhibition of c-Kit (unknown origin) using biotinylated HER2 peptide as substrate by time resolved fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112617(CHEMBL3608786)
Affinity DataEC50:  8.70nMAssay Description:Inhibition of collagen I-induced DDR2 (unknown origin) phosphorylation expressed in HEK293 cells after 16 hrs by mesoscale discovery assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)