BDBM50109532 CHEMBL3601223

SMILES CN1CCN(CC1)c2ccc(c(c2)OC)Nc3ncc(c(n3)NCc4cccc(c4)NC(=O)C=C)Cl

InChI Key InChIKey=UGXCBYVBIJACEK-UHFFFAOYSA-N

Data  11 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50109532   

TargetTyrosine-protein kinase JAK3(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of JAK3 (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ITK/TSK(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of ITK (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50: 794nMAssay Description:Inhibition of BTK (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50: 409nMAssay Description:Inhibition of wild type EGFR (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TYK2 (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of JAK2 (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50: 896nMAssay Description:Inhibition of JAK1 (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50: 36nMAssay Description:Inhibition of TXK (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50: 157nMAssay Description:Inhibition of BLK (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50: 49nMAssay Description:Inhibition of TTK (unknown origin) by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50109532(CHEMBL3601223)
Affinity DataIC50: 13nMAssay Description:Inhibition of FLT3 (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed