BDBM50104413 CHEMBL87796::Glutamyl-gamma-boronate analogue

SMILES B(CCC(C(=O)O)N)(O)O

InChI Key InChIKey=KSYFGBKMRXVJSG-UHFFFAOYSA-N

Data  4 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50104413   

TargetGlutamyl-tRNA(Gln) amidotransferase subunit C(Streptococcus pyogenes M1 GAS)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104413(Glutamyl-gamma-boronate analogue | CHEMBL87796)
Affinity DataIC50: 100nMAssay Description:In vitro inhibitory concentration against Glutaminase activity of bacterial Glu-tRNA-Gln aminotransferase (Glu-AdT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamyl-tRNA(Gln) amidotransferase subunit C(Streptococcus pyogenes M1 GAS)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104413(Glutamyl-gamma-boronate analogue | CHEMBL87796)
Affinity DataIC50: 1.60E+3nMAssay Description:In vitro inhibitory concentration against Glutaminase activity of bacterial Glu-tRNA-Gln aminotransferase (Glu-AdT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
State University of New York

Curated by ChEMBL
LigandPNGBDBM50104413(Glutamyl-gamma-boronate analogue | CHEMBL87796)
Affinity DataKi:  5nMAssay Description:Inhibition of GGT1 (unknown origin) transpeptidation assessed as inhibition constant using L-GpNA as substrate in presence of Gly-GlyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutathione hydrolase 1 proenzyme(Human)
State University of New York

Curated by ChEMBL
LigandPNGBDBM50104413(Glutamyl-gamma-boronate analogue | CHEMBL87796)
Affinity DataKi:  5.40nMAssay Description:Inhibition of human GGT1 transpeptidation in Pichia pastoris using L-GpNA as substrate in presence of Gly-GlyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutathione hydrolase 1 proenzyme(Human)
State University of New York

Curated by ChEMBL
LigandPNGBDBM50104413(Glutamyl-gamma-boronate analogue | CHEMBL87796)
Affinity DataKi:  25nMAssay Description:Inhibition of human GGT1 expressed in Pichia pastoris assessed as inhibition of GSH hydrolysis measured by L-glutamate release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutathione hydrolase 1 proenzyme(Human)
State University of New York

Curated by ChEMBL
LigandPNGBDBM50104413(Glutamyl-gamma-boronate analogue | CHEMBL87796)
Affinity DataKi:  25nMAssay Description:Inhibition of GGT1 (unknown origin) assessed as GSH hydrolysis by measuring inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)