BDBM50100518 CHEMBL3327064::US10377744, Compound No. 2389

SMILES CC(C)C(=O)N1CCC(CC1)NC(=O)Nc2ccc(cc2)C(F)(F)F

InChI Key InChIKey=KKMHGEIPUCNGMV-UHFFFAOYSA-N

Data  2 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50100518   

TargetBifunctional epoxide hydrolase 2(Mouse)
University of California

US Patent
LigandPNGBDBM50100518(CHEMBL3327064 | US10377744, Compound No. 2389)
Affinity DataIC50: 5.5nMAssay Description:fluoresence competitive assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2017
Entry Details
Go to US Patent

TargetBifunctional epoxide hydrolase 2(Mouse)
University of California

US Patent
LigandPNGBDBM50100518(CHEMBL3327064 | US10377744, Compound No. 2389)
Affinity DataIC50: 37.5nMAssay Description:Trans-diphenylpropene oxide is used in a radiometric competitive assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2017
Entry Details
Go to US Patent

TargetBifunctional epoxide hydrolase 2(Rat)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50100518(CHEMBL3327064 | US10377744, Compound No. 2389)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of rat soluble epoxide hydrolase using [3H]-t-DPPO as a substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50100518(CHEMBL3327064 | US10377744, Compound No. 2389)
Affinity DataKi:  0.660nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50100518(CHEMBL3327064 | US10377744, Compound No. 2389)
Affinity DataKi:  0.660nMAssay Description:FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)