BDBM50098550 3,N-Dimethyl-N-[(R)-1-methyl-3-(4-methyl-piperidin-1-yl)-propyl]-benzenesulfonamide::3,N-Dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl)-propyl]-benzenesulfonamide::3,N-Dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl)-propyl]-benzenesulfonamide (SB-258719)::4-Methyl-1-[(R)-3-methyl-4-(toluene-3-sulfonyl)-pentyl]-piperidine::CHEMBL12264::SB-258719

SMILES C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1

InChI Key InChIKey=AGVNHDNTFYHZNL-UHFFFAOYSA-N

Data  26 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50098550   

Target5-hydroxytryptamine receptor 7(Rat)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  31.6nMAssay Description:Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  31.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  31.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  32nMAssay Description:Antagonist activity at 5-HT7 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  32nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  32nMAssay Description:Binding affinity to 5-HT7 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  32nMAssay Description:Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  32nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  32nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  32nMAssay Description:Binding affinity to 5HT7 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2014
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  79nMAssay Description:Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi: >3.00E+3nMAssay Description:Antagonist activity at 5-HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  3.16E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  3.98E+3nMAssay Description:Displacement of [3H]raclopride from human dopamine receptor D2A expressed in mouse Ltk cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  3.98E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  3.98E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  5.01E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  5.01E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  6.31E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi: >7.94E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed