BDBM50095997 3',4',7-trihydroxyisoflavone::CHEMBL13486

SMILES c1cc(c(cc1C2=COc3cc(ccc3C2=O)O)O)O

InChI Key InChIKey=DDKGKOOLFLYZDL-UHFFFAOYSA-N

Data  3 KI  6 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50095997   

TargetDeath-associated protein kinase 1(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataIC50: 2.80E+5nMAssay Description:Displacement of ANS from DAPK1 catalytic domain (1 to 285) (unknown origin) after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetXanthine dehydrogenase/oxidase(Human)
Amorepacific

Curated by ChEMBL
LigandPNGBDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataIC50: 1.68E+4nMAssay Description:Inhibition of xanthine oxidase assessed as decrease of superoxide generationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Amorepacific

Curated by ChEMBL
LigandPNGBDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of xanthine oxidase assessed as decrease of uric acid generationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataIC50: 38nMAssay Description:Inhibition of human MIF tautomerase activity expressed in Escherichia coli BL21 (DE3) using 4-hydroxyphenyl pyruvic acid as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosinase(Mouse)
Amorepacific

Curated by ChEMBL
LigandPNGBDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataIC50: 5.23E+3nMAssay Description:Inhibition of tyrosinase in mouse Melan-a cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant human His-tagged MIF tautomerization expressed in Escherichia coli BL21 (DE3) using D-dopachrome as substrate after 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataKi:  38nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataKi:  38nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli using 4-hydroxyphenyl pyruvic acid as substrate assessed as bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)