BDBM50095474 CHEMBL3590478::US10329294, Example 2

SMILES Cn1cc(c(n1)C(F)(F)F)NC(=O)c2cnn3c2nc(cc3)N[C@@H]4CCCC[C@@H]4N

InChI Key InChIKey=LAXFSYWLDNVHAQ-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50095474   

LigandPNGBDBM50095474(CHEMBL3590478 | US10329294, Example 2)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human IRAK4 assessed as phosphorylation of fluorescent peptide substrate after 30 mins by fluorescent polarization readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50095474(CHEMBL3590478 | US10329294, Example 2)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50095474(CHEMBL3590478 | US10329294, Example 2)
Affinity DataIC50: 9nMAssay Description:Inhibition of IRAK4 in human PBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50095474(CHEMBL3590478 | US10329294, Example 2)
Affinity DataIC50: 0.5nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)