BDBM50093753 (2S,3S)-2-Amino-3-benzyloxy-succinic acid::(2S,3S)-2-amino-3-(benzyloxy)succinic acid::(3S)-3-(BENZYLOXY)-L-ASPARTIC ACID::CHEMBL79140::DL-TBOA

SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O

InChI Key InChIKey=BYOBCYXURWDEDS-UHFFFAOYSA-N

Data  3 KI  31 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50093753   

TargetExcitatory amino acid transporter 2(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 1.91E+3nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of [3H]-D-Asp uptake at human EAAT1 expressed in HEK293 cells measured after 3 mins by TopCount methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2018
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 960nMAssay Description:Inhibition of [3H]-D-Asp uptake at human EAAT2 expressed in HEK293 cells measured after 3 mins by TopCount methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2018
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of [3H]-D-Asp uptake at human EAAT3 expressed in HEK293 cells measured after 3 mins by TopCount methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2018
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 955nMAssay Description:Inhibition of [3H]-D-Asp uptake at human EAAT2 expressed in HEK293 cells measured after 3 mins by TopCount methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2018
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of [3H]-D-Asp uptake at human EAAT1 expressed in HEK293 cells measured after 3 mins by TopCount methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2018
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 3.72E+3nMAssay Description:Inhibition of [3H]-D-Asp uptake at human EAAT3 expressed in HEK293 cells measured after 3 mins by TopCount methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2018
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 4(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 2.29E+3nMAssay Description:Inhibition of rat EAAT4 expressed in tsA201 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of [14C]glutamate uptake at human EAAT3 expressed in african green monkey COS1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 4(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of rat EAAT4 expressed in tsA201 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 6.70E+4nMAssay Description:Inhibition of human EAAT1 transfected in African green monkey COS-1 cells assessed as reduction in [14C]glutamate uptake incubated for 12 mins by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of human EAAT2 transfected in African green monkey COS-1 cells assessed as reduction in [14C]glutamate uptake incubated for 12 mins by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetExcitatory amino acid transporter 3(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 7.00E+3nMAssay Description:Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human EAAC1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 6.40E+4nMAssay Description:Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 1.61E+5nMAssay Description:Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 6.37E+5nMAssay Description:Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 2.30E+4nMAssay Description:Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 1.61E+5nMAssay Description:Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 2.21E+5nMAssay Description:Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 1.00E+6nMAssay Description:Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 6.37E+5nMAssay Description:Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 3.80E+3nMAssay Description:Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 2.21E+5nMAssay Description:Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 2.10E+4nMAssay Description:Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor 3(Rat)
Suntory Institute For Bioorganic Research

Curated by PDSP Ki Database
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Suntory Institute For Bioorganic Research

Curated by PDSP Ki Database
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
Suntory Institute For Bioorganic Research

Curated by PDSP Ki Database
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed