BDBM50086441 CHEMBL3426225::US10266537, Compound 3

SMILES CCn1nc(C#Cc2cc(ccc2C)C(=O)Nc2ccc(CN3CCN(C)CC3)c(c2)C(F)(F)F)c2c(N)ncnc12

InChI Key InChIKey=BNRXMSGHPVYSDK-UHFFFAOYSA-N

Data  66 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 66 hits for monomerid = 50086441   

TargetProto-oncogene tyrosine-protein kinase Src [T341M](Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 30nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 17nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetBreakpoint cluster region protein [1-693](Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetTyrosine-protein kinase Blk(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 19nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetTyrosine-protein kinase Fyn(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 5nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetTyrosine-protein kinase Yes(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 27nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetSerine/threonine-protein kinase B-raf(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 92nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetSerine/threonine-protein kinase B-raf [V600E](Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 15nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetFibroblast growth factor receptor 1(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 3nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetProto-oncogene tyrosine-protein kinase Src [1-530](Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetTyrosine-protein kinase ABL1(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Pim1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PKBalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PKBbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 16nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetEphrin type-B receptor 2(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 26nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetEphrin type-B receptor 4(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 23nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetEpithelial discoidin domain-containing receptor 1(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 9nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetDiscoidin domain-containing receptor 2(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 128nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 7(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 61nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetHigh affinity nerve growth factor receptor(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 27nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 67nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetCytoplasmic tyrosine-protein kinase BMX(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 6nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 353nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 164nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetTyrosine-protein kinase receptor UFO(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 578nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetPlatelet-derived growth factor receptor alpha(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 890nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 2.91E+3nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetEpidermal growth factor receptor(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 3.52E+3nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetNUAK family SNF1-like kinase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Ark5More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 67nMAssay Description:Inhibition of human BtkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 353nMAssay Description:Inhibition of human IKKalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 164nMAssay Description:Inhibition of human IKKbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 578nMAssay Description:Inhibition of human AxlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 890nMAssay Description:Inhibition of human PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 2.91E+3nMAssay Description:Inhibition of human JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 3.52E+3nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Aurora-AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group C member 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 61nMAssay Description:Inhibition of human TAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK7More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TBK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human JNK1alpha1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
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