BDBM50086268 CHEMBL3425867

SMILES COc1cc(ccc1N)-c1cnc2c(snc2c1)N1CCOCC1

InChI Key InChIKey=AAUCXXCMBFZYRT-UHFFFAOYSA-N

Data  1 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50086268   

TargetCyclin-G-associated kinase(Human)
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50086268(CHEMBL3425867)
Affinity DataKd:  8.90nMAssay Description:Binding affinity to human GAK fused to T7 bacteriophage expressed in Escherichia coli BL21 after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50086268(CHEMBL3425867)
Affinity DataKd:  8.90nMAssay Description:Binding affinity to DNA-tagged human GAK expressed in Escherichia coli BL21 using immobilised ligand incubated for 1 hr by quantitative PCRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2020
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50086268(CHEMBL3425867)
Affinity DataKd:  4.5nMAssay Description:Inhibition of wild-type human partial length KIT (I571 to D952 residues) expressed in bacterial expression system by ATP-site competition binding ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2020
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50086268(CHEMBL3425867)
Affinity DataIC50: 51nMAssay Description:Inhibition of tracer 222 binding to GAK (unknown origin) incubated for 1 hr by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50086268(CHEMBL3425867)
Affinity DataKd:  8.90nMAssay Description:Binding affinity to GAK (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed