BDBM50080528 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide::4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione::CHEMBL123292::Cycloheximid::Zykloheximid::cid_6197::cycloheximide::med.21724, Compound Cycloheximide

SMILES C[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C

InChI Key InChIKey=YPHMISFOHDHNIV-UHFFFAOYSA-N

Data  7 KI  8 IC50  3 EC50

PDB links: 18 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50080528   

TargetCOUP transcription factor 2(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataIC50: 1.32E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2013
Entry Details
PCBioAssay
TargetTegument protein VP16(HHV-1)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataIC50: 8.54E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2014
Entry Details
PCBioAssay
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Human)
Max-Planck Research Unit

Curated by ChEMBL
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataIC50: 3.60E+3nMAssay Description:Compound was evaluated for its inhibitory effect on human FK506 binding protein 12 by means of protease-coupled PPIase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target60S ribosomal protein L19-A(Baker's yeast)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataEC50:  644nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2011
Entry Details
PCBioAssayPDB3D3D Structure (crystal)
TargetEukaryotic initiation factor 4A-I(Human)
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataIC50: 142nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetEukaryotic initiation factor 4A-I(Human)
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataIC50: 87nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetEukaryotic initiation factor 4A-I(Human)
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataIC50: 101nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetEukaryotic initiation factor 4A-I(Human)
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataIC50: 226nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataIC50: 36nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human HeLa cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
University of Bonn

LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataEC50:  189nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataEC50:  40nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Human)
Max-Planck Research Unit

Curated by ChEMBL
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataKi:  3.40E+3nMAssay Description:Binding affinity to FKBP12 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Human)
Max-Planck Research Unit

Curated by ChEMBL
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition constant(Ki) for inhibition of PPIase activity of human FK506 binding protein 12 (Conc=14 nM) of FKBPs familyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP4(Human)
Max-Planck Research Unit

Curated by ChEMBL
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataKi:  2.42E+4nMAssay Description:Inhibition constant(Ki) for inhibition of PPIase activity of rabbit FK506 binding protein 52 (Conc=52 nM) of FKBPs familyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP14(Human)
Max-Planck Research Unit

Curated by ChEMBL
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataKi:  7.62E+4nMAssay Description:Inhibition constant(Ki) for inhibition of PPIase activity of Photobacterium sp. FK506 binding protein 22 (Conc=41 nM) of FKBPs familyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Human)
Max-Planck Research Unit

Curated by ChEMBL
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition constant(Ki) for inhibition of PPIase activity of human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Conc=4 nM) of Parvulins fa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP3(Human)
Max-Planck Research Unit

Curated by ChEMBL
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataKi:  1.24E+5nMAssay Description:Inhibition constant(Ki) for inhibition of PPIase activity of Legionella pneumophilia FK506 binding protein 25 (Conc=40 nM) of FKBPs familyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase NIMA-interacting 4(Human)
Max-Planck Research Unit

Curated by ChEMBL
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataKi:  1.87E+5nMAssay Description:Inhibition constant(Ki) for inhibition of PPIase activity of Escherichia coli parvulin (Conc=4 nM) of Parvulins sfamilyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed