BDBM50072076 CHEMBL3407864

SMILES CN1C(=C(C(=O)N1c2ccccc2)C(=O)Nc3ccc(cn3)Oc4ccnc5c4cc(c(c5)OC)OC)c6ccncc6

InChI Key InChIKey=JZUVVTPSJAHDMJ-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50072076   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Amgen

Curated by ChEMBL

LigandBDBM50072076(CHEMBL3407864)Copy SMILESCopy InChI

Affinity DataIC50: 42nMAssay Description:Inhibition of human N-terminal His-tagged PERK expressed in Escherichia coli using AviTag C-terminal, N-terminal His-tagged eIF2alpha (3 to 315) as s...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/21/2016
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Amgen

Curated by ChEMBL

LigandBDBM50072076(CHEMBL3407864)Copy SMILESCopy InChI

Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IRE-1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/21/2016
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL