BDBM50069762 CHEMBL3182437::ML323::US9802904, 87

SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-n2ccnn2)n1

InChI Key InChIKey=VUIRVWPJNKZOSS-UHFFFAOYSA-N

Data  11 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50069762   

TargetUbiquitin carboxyl-terminal hydrolase 2(Human)
University of Delaware

LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: 1.14E+5nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Human)
University of Delaware

LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: 1.14E+5nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
University of Delaware

LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: 1.14E+5nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of USP1 (unknown origin) by Ub-Rho110 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2016
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: 76nMAssay Description:This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: 17nMAssay Description:This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetWD repeat-containing protein 48(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: 100nMAssay Description:Inhibition of human USP1/UAF1 using Ub-AMC substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetWD repeat-containing protein 48(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: 190nMAssay Description:Inhibition of human USP1/UAF1 using Ub-AMC substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetWD repeat-containing protein 48(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataEC50:  3.00E+3nMAssay Description:Inhibition of human USP1/UAF1 in human H1299 cells assessed as reduction in colony formation after 7 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetWD repeat-containing protein 48(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: 76nMAssay Description:Inhibition of human USP1/UAF1 using Ub-AMC substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetWD repeat-containing protein 48(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: 120nMAssay Description:Inhibition of human USP1/UAF1 using Ub-AMC substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetWD repeat-containing protein 48(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: 140nMAssay Description:Inhibition of human USP1/UAF1 using Ub-AMC substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed