BDBM50063783 1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-hex-5-yn-1-one::1-(3,5-di-tert-butyl-4-hydroxyphenyl)hex-5-yn-1-one::CHEMBL13878::TEBUFELONE

SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)C(=O)CCCC#C

InChI Key InChIKey=ZHXUEUKVDMWSKV-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50063783   

TargetProstaglandin G/H synthase 1(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063783(CHEMBL13878 | 1-(3,5-Di-tert-butyl-4-hydroxy-pheny...)
Affinity DataIC50: 250nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063783(CHEMBL13878 | 1-(3,5-Di-tert-butyl-4-hydroxy-pheny...)
Affinity DataIC50: 250nMAssay Description:Concentration (in uM) to inhibit 50% of Prostaglandin G/H synthase 1 (COX-1) and is expressed in IC50.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063783(CHEMBL13878 | 1-(3,5-Di-tert-butyl-4-hydroxy-pheny...)
Affinity DataIC50: 250nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063783(CHEMBL13878 | 1-(3,5-Di-tert-butyl-4-hydroxy-pheny...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of 5-Lipoxygenase (5-LOX)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063783(CHEMBL13878 | 1-(3,5-Di-tert-butyl-4-hydroxy-pheny...)
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063783(CHEMBL13878 | 1-(3,5-Di-tert-butyl-4-hydroxy-pheny...)
Affinity DataIC50: 100nMAssay Description:Concentration (in uM) to inhibit 50% of Prostaglandin G/H synthase 2 (COX-2) and is expressed in IC50.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063783(CHEMBL13878 | 1-(3,5-Di-tert-butyl-4-hydroxy-pheny...)
Affinity DataIC50: 3.00E+3nMAssay Description:The compound was tested for the concentration (in uM) to inhibit 50% of 5-Lipoxygenase (5-LOX) and is expressed in IC50.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063783(CHEMBL13878 | 1-(3,5-Di-tert-butyl-4-hydroxy-pheny...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of 1-lipoxygenase (LOX)in RBL cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063783(CHEMBL13878 | 1-(3,5-Di-tert-butyl-4-hydroxy-pheny...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed