BDBM50059523 (6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one::AACOCF3::Arachidonic acid trifluoromethyl ketone::Arachidonyl trifluoromethyl ketone::Arachidonyltrifluoromethane::CHEMBL281211

SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)C(F)(F)F

InChI Key InChIKey=PLWROONZUDKYKG-UHFFFAOYSA-N

Data  13 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50059523   

TargetCytosolic phospholipase A2(Bovine)
Ludwig-Maximilians University

Curated by ChEMBL
LigandPNGBDBM50059523(Arachidonyltrifluoromethane | (6Z,9Z,12Z,15Z)-1,1,...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against cPLA2 (cytosolic Phospholipase A2) by measuring the calcium ionophore A-23,187-induced arachidonic acid release from bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytosolic phospholipase A2(Bovine)
Ludwig-Maximilians University

Curated by ChEMBL
LigandPNGBDBM50059523(Arachidonyltrifluoromethane | (6Z,9Z,12Z,15Z)-1,1,...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of cPLA2 measuring Calcium ionophore A-23,187-induced arachidonic acid release from bovine platelets with HPLC/UV detection.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytosolic phospholipase A2(Human)
University of MüNster

Curated by ChEMBL
LigandPNGBDBM50059523(Arachidonyltrifluoromethane | (6Z,9Z,12Z,15Z)-1,1,...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human platelet cPLA2-alpha assessed as arachidonic acid release by vesicle assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytosolic phospholipase A2 gamma(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50059523(Arachidonyltrifluoromethane | (6Z,9Z,12Z,15Z)-1,1,...)
Affinity DataIC50: 420nMAssay Description:Concentration required to inhibit human Cytosolic phospholipase A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytosolic phospholipase A2 beta(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50059523(Arachidonyltrifluoromethane | (6Z,9Z,12Z,15Z)-1,1,...)
Affinity DataIC50: 800nMAssay Description:Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by soluble assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50059523(Arachidonyltrifluoromethane | (6Z,9Z,12Z,15Z)-1,1,...)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of human MGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50059523(Arachidonyltrifluoromethane | (6Z,9Z,12Z,15Z)-1,1,...)
Affinity DataIC50: 12.3nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetCytosolic phospholipase A2(Human)
University of MüNster

Curated by ChEMBL
LigandPNGBDBM50059523(Arachidonyltrifluoromethane | (6Z,9Z,12Z,15Z)-1,1,...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of cPLA2 from human platelets by RP-HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50059523(Arachidonyltrifluoromethane | (6Z,9Z,12Z,15Z)-1,1,...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of FAAH from rat brain microsomes by RP-HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50059523(Arachidonyltrifluoromethane | (6Z,9Z,12Z,15Z)-1,1,...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of fatty acid amide hydrolase; range =. 23-3 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetCytosolic phospholipase A2(Human)
University of MüNster

Curated by ChEMBL
LigandPNGBDBM50059523(Arachidonyltrifluoromethane | (6Z,9Z,12Z,15Z)-1,1,...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human platelet cPLA2-alpha activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50059523(Arachidonyltrifluoromethane | (6Z,9Z,12Z,15Z)-1,1,...)
Affinity DataIC50: 12.3nMAssay Description:Inhibition of human recombinant FAAH-maltose binding proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50059523(Arachidonyltrifluoromethane | (6Z,9Z,12Z,15Z)-1,1,...)
Affinity DataIC50: 6.46E+3nMAssay Description:Inhibition of human MGL activity using [3H]2-oleoylglycerol substrate by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
University of Kuopio

Curated by ChEMBL
LigandPNGBDBM50059523(Arachidonyltrifluoromethane | (6Z,9Z,12Z,15Z)-1,1,...)
Affinity DataEC50:  2.51E+4nMAssay Description:Displacement of [35S]GTP-gamma-S from rat cerebellar CB1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed