BDBM50058855 (S)-2-Butoxycarbonylamino-3-{2-[(R)-3-(4-carbamimidoyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-propionic acid; TFA::CHEMBL23743::CHEMBL64267

SMILES [H]/N=C(\c1ccc(cc1)C2=NO[C@H](C2)CC(=O)NC[C@@H](C(=O)O)NC(=O)OCCCC)/N

InChI Key InChIKey=SRRJCHGGTPFZSS-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50058855   

TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855(CHEMBL64267 | CHEMBL23743 | (S)-2-Butoxycarbonylam...)
Affinity DataIC50: 50nMAssay Description:Inhibition of platelet aggregation in citreated human platelet rich plasma (PRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855(CHEMBL64267 | CHEMBL23743 | (S)-2-Butoxycarbonylam...)
Affinity DataIC50: 0.25nMAssay Description:Affinity for purified human platelet glycoprotein alpha IIb beta3 integrin receptor in ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855(CHEMBL64267 | CHEMBL23743 | (S)-2-Butoxycarbonylam...)
Affinity DataIC50: 66nMAssay Description:Inhibition of platelet aggregation in heparin treated human platelet rich plasma (PRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855(CHEMBL64267 | CHEMBL23743 | (S)-2-Butoxycarbonylam...)
Affinity DataIC50: 21nMAssay Description:Inhibition of fibrinogen (Fg) interaction with GPIIb/IIIa in gel filtered plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855(CHEMBL64267 | CHEMBL23743 | (S)-2-Butoxycarbonylam...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of [125I]fibrinogen binding to purified platelet Fibrinogen ReceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855(CHEMBL64267 | CHEMBL23743 | (S)-2-Butoxycarbonylam...)
Affinity DataIC50: 11nMAssay Description:Inhibition of [125I]fibrinogen binding to activated human plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855(CHEMBL64267 | CHEMBL23743 | (S)-2-Butoxycarbonylam...)
Affinity DataIC50: 50nMAssay Description:In vitro inhibition of ADP-induced platelet aggregation in human platelet rich plasma (hPRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855(CHEMBL64267 | CHEMBL23743 | (S)-2-Butoxycarbonylam...)
Affinity DataIC50: 60nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)