BDBM50055908 CHEMBL3321925::US9884814, Compound 141

SMILES [H]/N=C(\N[C@H](Cc1ccccc1)C(=O)NCc2ccc(c(c2)OC)OC)/NC(=O)Cc3ccc(c(c3)OC)OC

InChI Key InChIKey=IZIUZEPBXLRZLW-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50055908   

TargetRenin(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50055908(CHEMBL3321925 | US9884814, Compound 141)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant renin using quenched Dabcyl-g-Abu-IHPFHLVIHT-Edans peptide substrate by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetCathepsin D(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50055908(CHEMBL3321925 | US9884814, Compound 141)
Affinity DataIC50: 58nMAssay Description:Inhibition of human liver cathepsin D using MCA-labeled GKPILFFRLK(Dnp)-D-R-NH2 peptide by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin D(Bovine)
Merck

Curated by ChEMBL
LigandPNGBDBM50055908(CHEMBL3321925 | US9884814, Compound 141)
Affinity DataIC50: 330nMAssay Description:Inhibition of cathepsin D in bovine cartilage explants assessed as reduction in sulphated GAGs level after 3 days by spectrophotometric 1,9-dimethylm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin D(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50055908(CHEMBL3321925 | US9884814, Compound 141)
Affinity DataIC50: 58nMpH: 5.5 T: 2°CAssay Description:In order to identify modulators of cathepsin D activity, a continuous enzymatic test was carried out with a synthetic peptide which carries a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)