BDBM50053584 CHEMBL1977874

SMILES CCN1C(=O)c2cc(c(nc2N(C1=O)C3CC3)N)C(=O)N

InChI Key InChIKey=HWODCHXORCTEGU-UHFFFAOYSA-N

Data  6 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50053584   

TargetEukaryotic elongation factor 2 kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50053584(CHEMBL1977874)
Affinity DataIC50: 280nMAssay Description:ATP competitive inhibition of human eEF-2K using 5 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEukaryotic elongation factor 2 kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50053584(CHEMBL1977874)
Affinity DataIC50: 420nMAssay Description:Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEukaryotic elongation factor 2 kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50053584(CHEMBL1977874)
Affinity DataIC50: 510nMAssay Description:Inhibition of eEF2K (unknown origin) using peptide MH-1 as substrate after 2 hrs by ADP-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEukaryotic elongation factor 2 kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50053584(CHEMBL1977874)
Affinity DataIC50: 280nMAssay Description:Inhibition of eEF2K (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEukaryotic elongation factor 2 kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50053584(CHEMBL1977874)
Affinity DataIC50: 420nMAssay Description:Inhibition of eEF2K (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEukaryotic elongation factor 2 kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50053584(CHEMBL1977874)
Affinity DataIC50: 280nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)