BDBM50051920 2,4-DIAMINO-6-[N-(3',4',5'-TRIMETHOXYBENZYL)-N-METHYLAMINO]PYRIDO[2,3-D]PYRIMIDINE::CHEMBL32190::N*6*-Methyl-N*6*-(3,4,5-trimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine

SMILES CN(Cc1cc(c(c(c1)OC)OC)OC)c2cc3c(nc(nc3nc2)N)N

InChI Key InChIKey=PUOZHLHNKHRTOW-UHFFFAOYSA-N

Data  6 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50051920   

TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051920(N*6*-Methyl-N*6*-(3,4,5-trimethoxy-benzyl)-pyrido[...)
Affinity DataIC50: 33nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051920(N*6*-Methyl-N*6*-(3,4,5-trimethoxy-benzyl)-pyrido[...)
Affinity DataIC50: 14nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051920(N*6*-Methyl-N*6*-(3,4,5-trimethoxy-benzyl)-pyrido[...)
Affinity DataIC50: 61nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051920(N*6*-Methyl-N*6*-(3,4,5-trimethoxy-benzyl)-pyrido[...)
Affinity DataIC50: 33nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051920(N*6*-Methyl-N*6*-(3,4,5-trimethoxy-benzyl)-pyrido[...)
Affinity DataIC50: 14nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051920(N*6*-Methyl-N*6*-(3,4,5-trimethoxy-benzyl)-pyrido[...)
Affinity DataIC50: 61nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed