BDBM50051293 (S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide::3-Hydroxy-2-phenyl-quinoline-4-carboxylic acid ((S)-1-phenyl-propyl)-amide::3-Hydroxy-2-phenyl-quinoline-4-carboxylic acid (1-phenyl-propyl)-amide::CHEMBL10188::SB 223412::SB-2234::SB-223412::Talnetant

SMILES CC[C@H](NC(=O)c1c(O)c(nc2ccccc12)-c1ccccc1)c1ccccc1

InChI Key InChIKey=BIAVGWDGIJKWRM-UHFFFAOYSA-N

Data  28 KI  10 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 50051293   

TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataIC50: 16.6nMAssay Description:Antagonist activity against human NK3 receptor expressed in HEK293 cells assessed as inhibition of NKB-induced increase of intracellular calcium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataIC50: 6.10nMAssay Description:Antagonist activity against human NK3 receptor expressed in HEK293 cells assessed as inhibition of increase of intracellular calcium level by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataIC50: 8.40nMAssay Description:Displacement of [125I]His3-MePhe7)-NKB from human NK3R expressed in CHO cell membranes by topcounting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2017
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataIC50: 2.40nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKd:  5.75nMAssay Description:Competitive inhibition at wild type human NK3 expressed in HEK293 cells assessed as decrease in [MePhe7]NKB-induced [3H]IP accumulation after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  1nMAssay Description:Binding Affinity of [125I]-MePhe7-NKB towards Tachykinin receptor 3-CHO cell membranes(n=3-8)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
In Depth
Date in BDB:
2/26/2012
Entry Details
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125 I]-[MePhe]-NKB binding to hNK-3-CHO (Chinese hamster ovary) membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I][MePhe7]neurokinin B from human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  2.51nMAssay Description:Displacement of [125I]-MePhe7-NKB from human NK3 receptor expressed in CHO cells after 90 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]osanetant from human recombinant NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Guinea pig)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor A1142.58T expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Guinea pig)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  7.40nMAssay Description:Binding affinity to human NK3 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]-SB222200 from recombinant human NK3R expressed in CHO cell membranes after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
Smithkline Beecham

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  144nMAssay Description:Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
Smithkline Beecham

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  144nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details
PubMed
TargetSubstance-K receptor(Human)
Smithkline Beecham

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  144nMAssay Description:Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Rat)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  190nMAssay Description:Binding affinity to rat NK3 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Rat)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  193nMAssay Description:Displacement of [3H]-SB222200 from rat NK3R after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Rat)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]-SB222200 from rat NK3R after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  254nMAssay Description:Binding affinity towards cloned human Tachykinin receptor 3 (hNK-3) expressed in CHO cells using [125I][MePhe7]-NKBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  1.86E+3nMAssay Description:Binding affinity towards human mu-opioid receptors in CHO (Chinese hamster ovary) cell linesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
Smithkline Beecham

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  3.70E+3nMAssay Description:Binding affinity to human NK2 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
Smithkline Beecham

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  3.98E+3nMAssay Description:Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human NK1 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
Smithkline Beecham

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details
PubMed
TargetSubstance-P receptor(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  1.26E+4nMAssay Description:Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed