BDBM50049805 CHEMBL169703::Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-ylmethyl]-amide::Tifluadom

SMILES CN1C(CNC(=O)c2ccsc2)CN=C(c2ccccc2F)c2ccccc12

InChI Key InChIKey=NPGABYHTDVGGJK-UHFFFAOYSA-N

Data  6 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50049805   

TargetGastrin/cholecystokinin type B receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049805(Tifluadom | Thiophene-3-carboxylic acid [5-(2-fluo...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049805(Tifluadom | Thiophene-3-carboxylic acid [5-(2-fluo...)
Affinity DataIC50: 47nMAssay Description:Inhibition of binding of [125I]CCK-8 to Cholecystokinin type A receptor in rat pancreasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50049805(Tifluadom | Thiophene-3-carboxylic acid [5-(2-fluo...)
Affinity DataKi:  0.170nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universitá

Curated by ChEMBL
LigandPNGBDBM50049805(Tifluadom | Thiophene-3-carboxylic acid [5-(2-fluo...)
Affinity DataKi:  0.780nMAssay Description:Binding affinity against Opioid receptor kappa 1 of guinea pig using [3H]U-65693 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Universitá

Curated by ChEMBL
LigandPNGBDBM50049805(Tifluadom | Thiophene-3-carboxylic acid [5-(2-fluo...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity against Opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049805(Tifluadom | Thiophene-3-carboxylic acid [5-(2-fluo...)
Affinity DataKi:  47nMAssay Description:Binding affinity against Cholecystokinin type A receptor using [125I](BH)-CCK-8 as radioligand in rat pancreas.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Universitá

Curated by ChEMBL
LigandPNGBDBM50049805(Tifluadom | Thiophene-3-carboxylic acid [5-(2-fluo...)
Affinity DataKi:  153nMAssay Description:Binding affinity against Opioid receptor delta 1 using [3H]DADLE as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049805(Tifluadom | Thiophene-3-carboxylic acid [5-(2-fluo...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed