BDBM50040867 CHEMBL3353206::US9586948, Example 25

SMILES Cn1cc(cn1)-c1cccc(n1)C(=O)Nc1cn(C)nc1C(N)=O

InChI Key InChIKey=XTVOMCVEGADMQN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50040867   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040867(CHEMBL3353206 | US9586948, Example 25)
Affinity DataIC50: 32nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040867(CHEMBL3353206 | US9586948, Example 25)
Affinity DataIC50: 32nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040867(CHEMBL3353206 | US9586948, Example 25)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged full-length IRAK4 expressed in baculovirus infected Sf9 insect cells using 5FAM-RKRQGSVRRRVH-CO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040867(CHEMBL3353206 | US9586948, Example 25)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040867(CHEMBL3353206 | US9586948, Example 25)
Affinity DataIC50: 138nMAssay Description:Inhibition of recombinant N-terminal GST-tagged full-length IRAK4 in human THP1-XBlue cells assessed as decrease in NF-kappaB level preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040867(CHEMBL3353206 | US9586948, Example 25)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040867(CHEMBL3353206 | US9586948, Example 25)
Affinity DataIC50: 138nMAssay Description:Inhibition of recombinant N-terminal GST-tagged full-length IRAK4 in human THP1-XBlue cells assessed as decrease in NF-kappaB level preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040867(CHEMBL3353206 | US9586948, Example 25)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged full-length IRAK4 expressed in baculovirus infected Sf9 insect cells using 5FAM-RKRQGSVRRRVH-CO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed